Posted by admin on
August 1, 2008
What Is Asthma?
Asthma (Az-muh) is a chronic disease that affects your airways. The airways are the tubes that carry air in and out of your lungs. If you have asthma, the inside walls of your airways are inflamed (swollen). The inflammation (IN-fla-MAY-shun) makes the airways very sensitive, and they tend to react strongly to things that you are allergic to or find irritating. When the airways react, they get narrower, and less air flows through to your lung tissue.
Like any other chronic disease, asthma is a condition you live with every day of your life. You can have an attack any time you are exposed to one of your triggers. Unlike other chronic obstructive lung diseases, asthma is reversible.
What Causes Asthma? It is not clear exactly what makes the airways of people with asthma inflamed in the first place. Your inflamed airways may be due to a combination of things. We know that if other people in your family have asthma, you are more likely to develop it.
Metabisulfite - a food preservative found in dried fruits, fruit juices, beer, wine, salad bars and vegetables.
Respiratory infections, such as colds, flu, sore throat and bronchitis.
Exposure to a variety of occupational irritants (e.g., vapors, dust, gases, fumes, tobacco smoke, air pollution) also can worsen or cause asthma.
Asthma Symptoms Wheezing is a musical, whistling, or hissing sound with breathing. Wheezes are most often heard during exhalation, but they can occur during breathing in (inhaling).
Asthma is characterized by inflammation of the bronchial tubes with increased production of sticky secretions inside the tubes. Not all children with asthma wheeze. Chronic coughing with asthma may be the only obvious sign, and a child’s asthma may go unrecognized if the cough is attributed to recurrent bronchitis.
How to Prevent Asthma Attacks: There are a few ways to prevent asthma symptoms from intensifying into an asthma attack: Follow your asthma treatment plan, including taking all of your meds as prescribed Avoid your asthma triggers as much as possible Identify asthma control problems before things get bad enough to cause symptoms by using a peak flow meter.
Does Asthma Increase Adult Suicide Risk? The study is the first to examine the association between asthma and suicidal thinking with and without suicide attempts using a nationally representative sample of adults.
It did not address the issue of whether asthma treatment increases suicide risk a topic that has been in the news since early this spring, when the FDA announced an investigation of a possible link between a widely prescribed allergy and asthma drug and suicide.
Treatment Of Asthma Treatment is aimed at avoiding known allergens and respiratory irritants and controlling symptoms and airway inflammation through medication.
There are two basic kinds of medication for the treatment of asthma:
Long-term control medications are used on a regular basis to prevent attacks, not for treatment during an attack. Types include:
Inhaled steroids (such as Azmacort, Vanceril, AeroBid, Flovent) prevent inflammation
Leukotriene inhibitors (such as Singulair and Accolate)
Anti-IgE therapy (Xolair), a medicine given by injection to patients with more severe asthma
Posted by admin on
April 14, 2008
Description
Singulair (Montelukast sodium) is a leukotriene (loo-koe-try-een) inhibitor. Leukotrienes are substances in the body that are associated with the inflammation and constriction of airway muscles and the accumulation of fluid in the lungs, all of which occur during an asthma attack.
Montelukast is used to prevent asthma attacks. Montelukast is also used in the treatment of seasonal nasal allergies.
Montelukast may also be used for purposes other than those listed in this medication guide.
Montelukast will not stop an asthma attack that has already begun. It is used to prevent asthmatic attacks.
Ingredients
Montelukast sodium is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor.
Montelukast sodium is described chemically as [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid, monosodium salt.
The empirical formula is C35H35ClNNaO3S, and its molecular weight is 608.18.
Montelukast sodium is a hygroscopic, optically active, white to off-white powder. Montelukast sodium is freely soluble in ethanol, methanol, and water and practically insoluble in acetonitrile.
Each 10-mg film-coated Singulair tablet contains 10.4 mg montelukast sodium, which is the molar equivalent to 10.0 mg of free acid, and the following inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, hydroxypropyl cellulose, and magnesium stearate. The film coating consists of: hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, red iron oxide, yellow iron oxide, and carnauba wax.
Recommendations
Follow the directions for using this medicine provided by your doctor. This medicine may come with a patient leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. This medicine may be taken on an empty stomach or with food. Generally, if this medicine is being taken for asthma, it is taken once daily in the evening. If taking for hay fever (seasonal allergic rhinitis), take the medicine at about the same time each day (either morning or evening). If you are taking for both asthma and hay fever, take the medicine in the evening.
STORE THIS MEDICINE at room temperature 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.
CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE use it as soon as your remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
Precautions
THIS MEDICINE WILL NOT STOP AN ASTHMA ATTACK once one has started. IF YOU ARE ALSO USING A BRONCHODILATOR INHALER, be sure to always carry the inhaler with you to use during asthma attacks. Consult your doctor or pharmacist for specific advice on all drug therapy.
CONTACT YOUR DOCTOR PROMPTLY IF YOUR SYMPTOMS DO NOT IMPROVE or if they become worse while you are using this medicine. CONTACT YOUR DOCTOR PROMPTLY if your short-acting inhaler use increases or if use exceeds the 24-hour maximum prescribed by the doctor.
DO NOT STOP USING THIS MEDICINE, or other asthma medicines, without first checking with your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine.
BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist.
FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy.
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